Molecular glue degraders enhance CAPRIN1-dependent lysosomal degradation of APP in Alzheimer disease
Sung Han Jung, Raktim N. Roy, Xu Wang, Bin Liu, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Li‐Fan Zeng, Ho-Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Anantha Shekhar, Anita C. Bellail, Chunhai Hao
The paper identifies molecular glue degraders that selectively degrade APP via CAPRIN1-dependent lysosomal pathway in neurons, reducing Aβ production in AD mouse models.
bioRxiv · Dec 29, 2023 · PreprintNeuroscience