Nancy Jaiswal

Intra-DNA k-mer Conservation Patterns Encode Evolutionary Selection of Variants

The paper introduces kGain, a metric quantifying k-mer frequency shifts due to mutations, and shows it predicts adaptive potential across species and experimental systems.

''Self-gapping'' by a C-terminal domain arginine finger regulates GTP hydrolysis in bacterial zinc metallochaperones

This paper identifies a 'self-gapping' mechanism in bacterial COG0523 metallochaperones where the C-terminal domain activates GTP hydrolysis via an arginine finger and lysine residue, revealing a novel regulatory mechanism.

Molecular glue degraders enhance CAPRIN1-dependent lysosomal degradation of APP in Alzheimer disease

The paper identifies molecular glue degraders that selectively degrade APP via CAPRIN1-dependent lysosomal pathway in neurons, reducing Aβ production in AD mouse models.