Thomas Dos Santos

The paper shows tropomodulin and leiomodin nucleate tropomyosin clusters on actin filaments, with tropomodulin acting at the pointed end and leiomodin along the entire filament.

This study investigates how cofilin binds and severs actin filaments containing ADP-Pi-actin, revealing that cofilin clusters form preferentially on ADP-actin subunits and severing is slower at ADP-Pi-actin boundaries.

The paper introduces a drag flow method to study protein-protein interactions, showing that low forces detach tropomyosin clusters from actin filaments, with detachment rates depending on isoform and force magnitude.

This paper develops virus-like particles (VLPs) displaying ECM peptides to control cell functions and demonstrates their effectiveness in promoting adhesion, migration, proliferation, and differentiation.