Hugo Wioland

The paper shows tropomodulin and leiomodin nucleate tropomyosin clusters on actin filaments, with tropomodulin acting at the pointed end and leiomodin along the entire filament.

This study investigates how cofilin binds and severs actin filaments containing ADP-Pi-actin, revealing that cofilin clusters form preferentially on ADP-actin subunits and severing is slower at ADP-Pi-actin boundaries.

The paper investigates how DAAM1 formin and Ena/VASP proteins assemble distinct actin filament networks at focal adhesions, showing different roles in focal adhesion dynamics.

This study compares actin filament assembly and disassembly kinetics between two yeast species and mammalian actin, revealing faster aging in yeast actins due to the absence of histidine 73 methylation.

The paper introduces a drag flow method to study protein-protein interactions, showing that low forces detach tropomyosin clusters from actin filaments, with detachment rates depending on isoform and force magnitude.

This study investigates the mechanism of vimentin filament disassembly, revealing continuous self-repair and subunit exchange dynamics that prevent fragmentation.

This study shows that HIV-1 budding requires MICAL1-mediated actin disassembly at the plasma membrane, with Rab35 also playing a role in this process.