Javier Escudero Morlanes

SIMPlex generates matched spatial and single-nucleus transcriptomic profiles from the same tissue section to resolve cell states with spatial signatures in mouse and human cancer tissues.

The paper creates a spatial transcriptomic atlas of pediatric brain tumors, identifying spatial archetypes and relapse-associated clones across multiple diagnoses.

The paper uses spatial and single-cell techniques to show T and B cell clonal expansion in CXCL9-rich niches of sinonasal cancer, linking immune hubs to tumor regions.

The paper introduces MAGPIE, a framework for integrating spatial transcriptomics, metabolomics, and tissue morphology data, demonstrating its application in studying drug-induced pulmonary fibrosis.

This study introduces a method to generate high-quality single-nucleus transcriptomic data from FFPE samples using recent single-cell genomic technology.