Author

Anna-Karina Felder

Royal Netherlands Academy of Arts and SciencesORCID 0000-0002-8895-9798Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:Hi-C· 1 Organism:human· 1

Frequent Co-Authors

Marjon J.A.M. Verstegen· 2 shared Peter H.L. KrijgeriD· 2 shared Sjoerd J. D. TjalsmaiD· 2 shared Wouter L. de LaatiD· 2 shared Christian Valdes‐QuezadaiD· 1 shared Emile van den AkkeriD· 1 shared Han J. M. P. VerhageniD· 1 shared Konstantinos Sofiadis· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMolecular Biology

Marjon J.A.M. Verstegen

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2 papers

Recent·Most cited

Reactivation of developmentally silenced globin genes through genomic deletions reveals that enhancer distance matters

Anna-Karina Felder, Sjoerd J. D. Tjalsma, Han J. M. P. Verhagen, Rezin Majied, Marjon J.A.M. Verstegen, Thijs C. J. Verheul, Rebecca Mohnani, Richard Gremmen, Peter H.L. Krijger, Sjaak Philipsen, Emile van den Akker, Wouter L. de Laat

The paper shows that deleting intervening DNA can bring enhancers closer to silenced genes, reactivating their expression in adult cells.

bioRxiv · Jan 13, 2025 · PreprintMolecular Biology

Building regulatory landscapes: enhancer recruits cohesin to create contact domains, engage CTCF sites and activate distant genes

Niels J. Rinzema, Konstantinos Sofiadis, Sjoerd J. D. Tjalsma, Marjon J.A.M. Verstegen, Yuva Öz, Christian Valdes‐Quezada, Anna-Karina Felder, Teodora Filipovska, Stefan van der Elst, Zaria de Andrade dos Ramos, Ruiqi Han, Peter H.L. Krijger, Wouter L. de Laat

This study shows enhancers recruit cohesin to form chromatin domains, engage CTCF sites, and activate distant genes, with transcription factors and mediator required for all distances but cohesin specifically for long-range activation.

bioRxiv · Oct 5, 2021 · PreprintMolecular Biology