Author

Marjon J.A.M. Verstegen

University Medical Center Utrecht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Assay:Hi-C· 2 Organism:human· 2

Frequent Co-Authors

Peter H.L. KrijgeriD· 4 shared Wouter L. de LaatiD· 4 shared Amin AllahyariD· 2 shared Anna-Karina FelderiD· 2 shared Elzo de WitiD· 2 shared Ruiqi HaniD· 2 shared Sjoerd J. D. TjalsmaiD· 2 shared Benjamin D. RowlandiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersMolecular Biology

Peter H.L. KrijgerORCID

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Author profile →

4 papers

Recent·Most cited

Reactivation of developmentally silenced globin genes through genomic deletions reveals that enhancer distance matters

Anna-Karina Felder, Sjoerd J. D. Tjalsma, Han J. M. P. Verhagen, Rezin Majied, Marjon J.A.M. Verstegen, Thijs C. J. Verheul, Rebecca Mohnani, Richard Gremmen, Peter H.L. Krijger, Sjaak Philipsen, Emile van den Akker, Wouter L. de Laat

The paper shows that deleting intervening DNA can bring enhancers closer to silenced genes, reactivating their expression in adult cells.

bioRxiv · Jan 13, 2025 · PreprintMolecular Biology

Detailed in vivo characterization of the players and impact of individual loop extrusion trajectories

Ruiqi Han, Yike Huang, Michelle Robers, Mikhail D. Magnitov, Iwan Vaandrager, Amin Allahyar, Marjon J.A.M. Verstegen, Kexin Zhang, Elzo de Wit, Wouter L. de Laat, Peter H.L. Krijger

This study uses TACL to analyze individual cohesin loop extrusion trajectories in vivo, revealing new roles for cohesin subunits and their interactions with CTCF and chromatin structure.

bioRxiv · Jan 4, 2023 · PreprintGenomics

Building regulatory landscapes: enhancer recruits cohesin to create contact domains, engage CTCF sites and activate distant genes

Niels J. Rinzema, Konstantinos Sofiadis, Sjoerd J. D. Tjalsma, Marjon J.A.M. Verstegen, Yuva Öz, Christian Valdes‐Quezada, Anna-Karina Felder, Teodora Filipovska, Stefan van der Elst, Zaria de Andrade dos Ramos, Ruiqi Han, Peter H.L. Krijger, Wouter L. de Laat

This study shows enhancers recruit cohesin to form chromatin domains, engage CTCF sites, and activate distant genes, with transcription factors and mediator required for all distances but cohesin specifically for long-range activation.

bioRxiv · Oct 5, 2021 · PreprintMolecular Biology

Locus-Specific Enhancer Hubs And Architectural Loop Collisions Uncovered From Single Allele DNA Topologies

Amin Allahyar, Carlo Vermeulen, Britta A. M. Bouwman, Peter H.L. Krijger, Marjon J.A.M. Verstegen, Geert Geeven, Melissa van Kranenburg, Mark Pieterse, Roy Straver, Judith H.I. Haarhuis, Kees Jalink, Hans Teunissen, Ivo Renkens, Wigard P. Kloosterman, Benjamin D. Rowland, , Wouter L. de Laat

The paper introduces a new 3C method, MC-4C, to study multi-way DNA conformations and reveals cooperative and competitive chromatin interactions, including enhancer hubs and loop collisions.

Nature Genetics · Jul 6, 2018Peer-reviewedGenetics