Author

Emil L. Kristoffersen

Aarhus UniversityORCID 0000-0001-8965-8201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Ebbe Sloth AnderseniD· 3 shared Nikolaj Holck ZwergiusiD· 2 shared Amanda Dyrholm StangeiD· 1 shared Andriy KryshtafovychiD· 1 shared Anna LewickaiD· 1 shared Anna‐Lena SteckelbergiD· 1 shared Cameron D. MackerethiD· 1 shared Christopher P. JonesiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

Ebbe Sloth AndersenORCID

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3 papers

Recent·Most cited

Fluorinated RNA origami enables serum-stable nanodevices for sensing and targeting

Emil L. Kristoffersen, Nikolaj Holck Zwergius, Néstor Sampedro Vallina, Amanda Dyrholm Stange, Lasse Messell Desdorf, Sofie Thomsen, Victoria Birkedal, Nicolas Glück, Laia Civit, Cody W. Geary, Jørgen Kjems, Julián Valero, Ebbe Sloth Andersen

This paper introduces FY-RNA origami structures that are serum-stable and capable of molecular sensing and targeting, revealing structural insights through cryo-EM and simulations.

bioRxiv · Mar 4, 2026 · PreprintBiochemistry

Functional relevance of CASP16 nucleic acid predictions as evaluated by structure providers

Rachael C. Kretsch, Reinhard Albrecht, Ebbe Sloth Andersen, Hsuan‐Ai Chen, Wah Chiu, Rhiju Das, Jeanine Gezelle, Marcus D. Hartmann, Claudia Höbartner, Yimin Hu, Shekhar Jadhav, Philip E. Johnson, Christopher P. Jones, Deepak Koirala, Emil L. Kristoffersen, , Andriy Kryshtafovych

Structure providers for 18 CASP16 nucleic acid targets find blind predictions capture secondary structure but miss non-canonical interactions, backbone kinks, ligand sites, and intermolecular interfaces.

Proteins Structure Function and Bioinformatics · Sep 4, 2025Peer-reviewedBiophysics✦ In-depth digest

Roles of dimeric intermediates in RNA-catalyzed rolling circle synthesis

Emil L. Kristoffersen, Ewan K.S. McRae, Niels R. Sørensen, Philipp Holliger, Ebbe Sloth Andersen

This study uses cryo-EM to characterize dimeric intermediates in RNA-catalyzed rolling circle synthesis, revealing their structural diversity and potential role in RNA replication.

Nucleic Acids Research · Jan 21, 2025Peer-reviewedBiochemistry