A Genome-Wide CRISPR Screen Identifies Sortilin as the Receptor Responsible for Galectin-1 Lysosomal Trafficking
Justin Donnelly, Roarke A. Kamber, Simon Wisnovsky, David S. Roberts, Egan L. Peltan, Michael Cory Bassik, Carolyn Ruth Bertozzi
The paper identifies sortilin as the receptor mediating galectin-1 lysosomal trafficking through a CRISPR screen and demonstrates its use for siRNA delivery.
bioRxiv · Jan 3, 2024 · PreprintMolecular Biology