Kaivalya Shevade

The paper introduces Plexus, a self-supervised model for capturing neuronal activity dynamics, and demonstrates its effectiveness in identifying genetic modifiers of neuronal activity in frontotemporal dementia.

The paper introduces CAT-ATAC, a method combining CRISPR, RNA, and ATAC-seq in single cells to identify gene regulatory relationships and validate them with loss-of-function experiments.

The paper develops a SAMHD1 knockout iPSC model that enhances lentiviral transduction efficiency in myeloid cells, enabling better functional genomics studies in innate immunity and inflammatory diseases.

This paper optimizes CRISPR guide RNA library cloning to reduce bias and enables more compact genetic screens with equivalent results using fewer cells.