Author

Merlin Schwan

Heidelberg UniversityORCID 0000-0003-3089-6963Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Organism:non-human primate· 1

Frequent Co-Authors

Irmgard SinningiD· 3 shared Dirk FlemmingiD· 2 shared Jürgen Kopp· 2 shared Annabelle Carolin WeldertiD· 1 shared Ariane F. FreyiD· 1 shared Attila HorváthiD· 1 shared Axel MogkiD· 1 shared Bernd BukauiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiochemistry

Irmgard SinningORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistryiSciencePeer-reviewedSep 22, 2026

Small-molecule activators of the Staphylococcus aureus ClpC/ClpP AAA+ protease

Timo Jenne, Vsevolod Viliuga, Ulrike Uhrig…·Axel Mogk

The paper identifies small-molecule activators of the Staphylococcus aureus ClpC/ClpP protease through high-throughput screening and characterizes their binding sites.

DOI 10.1016/j.isci.2026.117738

non-human primatebiophysical modeling

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Molecular BiologyiSciencePeer-reviewedAug 6, 2025

DNA-encoded Library Screening Uncovers Potent DNMT2 Inhibitors Targeting a Cryptic Allosteric Binding Site

Ariane F. Frey, Merlin Schwan, Annabelle Carolin Weldert…·Fabian Barthels

This study identifies potent DNMT2 inhibitors through DNA-encoded library screening, revealing a cryptic allosteric binding site and optimizing an inhibitor with low nanomolar affinity.

4 citations

humanexperimental assay

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BiochemistryNature Structural & Molecular BiologyPeer-reviewedJan 20, 2025

Structures of aberrant spliceosome intermediates on their way to disassembly

Komal Soni, Attila Horváth, Olexandr Dybkov…·Irmgard Sinning

The paper reports cryo-EM structures of aberrant spliceosome intermediates in S. pombe, revealing how a helicase-protein pair maintains catalytic dormancy and facilitates disassembly.

15 citations

yeastcryo-EM

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