Author

Fabian Barthels

Johannes Gutenberg University MainzORCID 0000-0001-7950-2158Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

Annabelle Carolin WeldertiD· 1 shared Antonia KieneiD· 1 shared Ariane F. FreyiD· 1 shared Bjarne KlopproggeiD· 1 shared Christiane EhrtiD· 1 shared Collin ZimmeriD· 1 shared D. OberthüeriD· 1 shared Emilie ScheeriD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Annabelle Carolin WeldertORCID

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2 papers

Recent·Most cited

DNA-encoded Library Screening Uncovers Potent DNMT2 Inhibitors Targeting a Cryptic Allosteric Binding Site

Ariane F. Frey, Merlin Schwan, Annabelle Carolin Weldert, Valerie Kadenbach, Jürgen Kopp, Zarina Nidoieva, Robert A. Zimmermann, Lukas Gleue, Collin Zimmer, Marko Jörg, Kristina Friedland, Mark Helm, Irmgard Sinning, Fabian Barthels

This study identifies potent DNMT2 inhibitors through DNA-encoded library screening, revealing a cryptic allosteric binding site and optimizing an inhibitor with low nanomolar affinity.

iScience · Aug 6, 2025Peer-reviewedMolecular Biology

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

Viviane Kremling, Sven Falke, Yaiza Fernández-García, Christiane Ehrt, Antonia Kiene, Bjarne Klopprogge, Emilie Scheer, Fabian Barthels, Philipp Middendorf, Sebastian Kühn, Stephan Günther, Matthias Rarey, Henry N. Chapman, D. Oberthüer, Janina Sprenger

The paper identifies ligands binding to the SARS-CoV-2 nsp10-16 complex using X-ray crystallography and reports their structures, providing insights for drug discovery.

bioRxiv · Mar 13, 2024 · PreprintBiochemistry