Gavin Spillard

Vascular and synaptic proteomes reveal blood-brain barrier disruption and postsynaptic remodeling in human temporal lobe epilepsy

This study identifies molecular changes in vascular and synaptic proteomes of human temporal lobe epilepsy, revealing BBB disruption and synaptic remodeling.

Multiomic profiling reveals pericyte and smooth muscle cell contributions to CADASIL pathology in cell-specific Notch3 mutant mice

This study uses mouse models to show that Notch3 mutations in pericytes and smooth muscle cells cause distinct vascular and neuroinflammatory changes in CADASIL.

Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes

The paper characterizes human iPSC-derived brain pericytes, showing they closely resemble primary pericytes in protein composition and function, and demonstrate therapeutic potential in neurological disorders.