Kassandra Kisler

Multiomic profiling reveals pericyte and smooth muscle cell contributions to CADASIL pathology in cell-specific Notch3 mutant mice

This study uses mouse models to show that Notch3 mutations in pericytes and smooth muscle cells cause distinct vascular and neuroinflammatory changes in CADASIL.

Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk

This study shows that transplanting iPSC-derived neural progenitor cells improves long-term recovery after stroke in mice by promoting tissue repair and reducing neurological deficits.

A molecular brain atlas reveals cellular shifts during the repair phase of stroke

This study creates a single-cell transcriptomic atlas of the mouse brain after stroke, revealing cell-specific molecular changes and shared features with human stroke lesions.

Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia

This study shows that iPSC-derived pericytes retain key functions under hypoxia, suggesting their potential for treating ischemic and neurodegenerative disorders.

Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes

The paper characterizes human iPSC-derived brain pericytes, showing they closely resemble primary pericytes in protein composition and function, and demonstrate therapeutic potential in neurological disorders.