Casey Griffin

This study uses hESCs to model Nager and Rodriguez syndromes, showing SF3B4 is essential for neural crest cell survival, maintenance, and differentiation.

This study shows that homozygous sf3b4 deletion in Xenopus tropicalis causes splicing defects and gene dysregulation, disrupting cranial neural crest development and leading to Nager syndrome-like features.

The paper characterizes human iPSC-derived brain pericytes, showing they closely resemble primary pericytes in protein composition and function, and demonstrate therapeutic potential in neurological disorders.

This study identifies Npr3's dual role in regulating neural crest and cranial placode progenitor formation through clearance and signaling functions in natriuretic peptide signaling.