Marcelo P. Coba

This study identifies molecular changes in vascular and synaptic proteomes of human temporal lobe epilepsy, revealing BBB disruption and synaptic remodeling.

This study uses mouse models to show that Notch3 mutations in pericytes and smooth muscle cells cause distinct vascular and neuroinflammatory changes in CADASIL.

This study shows that disrupting the SYNGAP1 PDZ ligand motif speeds up differentiation of human iPSC-derived GABAergic neurons, revealing its role in neuronal maturation.

The paper characterizes human iPSC-derived brain pericytes, showing they closely resemble primary pericytes in protein composition and function, and demonstrate therapeutic potential in neurological disorders.

The paper shows transcript errors generate amyloid and prion-like proteins in human cells, linking DNA damage to aging and disease.

This study shows SYNGAP1, an autism risk gene, is expressed in human cortical progenitors and its dysfunction disrupts neurogenesis and cortical lamination.

The paper shows that specific SynGAP splice variants improve cognitive function and reduce seizures in mice.

The paper investigates how the SynGAP-1 PBM regulates NMDA receptor signaling and cognitive function in mice, finding that disrupting the PBM leads to synaptic and cognitive impairments.