Author

Wenhui Sophia Lu

Stanford UniversityORCID 0009-0004-6293-0737Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:deep learning· 1 Research Focus:fine-mapping· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Research Focus:protein design· 1

Frequent Co-Authors

Balasubramanian NarasimhaniD· 1 shared Ben T ViggianoiD· 1 shared Bingfei YuiD· 1 shared Crystal Lee MackalliD· 1 shared Elena SotilloiD· 1 shared Euan Angus AshleyiD· 1 shared Geonhu LeeiD· 1 shared Haoyu DaiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Balasubramanian NarasimhanORCID

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2 papers

Recent·Most cited

CuGen: A GPU-accelerated framework for large-scale genomics

Tuomo Kiiskinen, Joshua Richland, W Wang, Wenhui Sophia Lu, Balasubramanian Narasimhan, Trevor J. Hastie, Robert John Tibshirani, Manuel A. Rivas

CuGen is a GPU-accelerated framework for large-scale genomics that enables efficient GWAS and fine-mapping with robust confounding control.

medRxiv · Jul 17, 2026 · PreprintGenetic & Genomic Medicine

Generative steering to adapt proteins beyond native biological contexts

Xiaowei Zhang, Wenhui Sophia Lu, Ben T Viggiano, Kevin Reynolds, Sophia Burick, Elena Sotillo, Haoyu Dai, Geonhu Lee, Zixuan Liu, Nuoya Yang, Luis Santiago Mille, Euan Angus Ashley, Bingfei Yu, Crystal Lee Mackall, Wing Hung Wong, Xiaojing J. Gao

ProVADA adapts proteins to non-native contexts by steering a pretrained generator while preserving function, successfully converting renin and deimmunizing antibodies.

bioRxiv · Jul 11, 2025 · PreprintBioengineering