Sebastian Leimbacher

Loss-of-function of the Zinc Finger Homeobox 4 (ZFHX4) gene underlies a neurodevelopmental disorder

This study identifies ZFHX4 loss-of-function variants as a cause of a neurodevelopmental disorder with distinctive facial features and brain abnormalities, supported by zebrafish models.

Non-coding structural variants identify a commonly affected regulatory region steering FOXG1 transcription in early neurodevelopment

The paper identifies a regulatory region affecting FOXG1 transcription in neurodevelopment through structural variants and chromatin analysis.

Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression

The paper shows that noradrenaline release from the locus coeruleus regulates gene expression in the hippocampus via beta-adrenergic receptors, with astrocyte-specific genes as key targets.