Mattia Privitera

GrimACE is an automated tool for assessing pain and well-being in mice using computer vision, showing high correlation with expert evaluations and detecting pain and treatment effects.

This paper introduces behavioral flow analysis to detect latent phenotypes in rodent behavior, improving statistical power and transferability across experiments.

This paper introduces a novel GR degrader, KH-103, which selectively degrades glucocorticoid receptors and shows improved efficacy over existing inhibitors.

The paper identifies hypothalamic MCH cells as a neural module that tracks and controls exploratory rearing through interactions with locus coeruleus neurons.

The paper shows that noradrenaline release from the locus coeruleus regulates gene expression in the hippocampus via beta-adrenergic receptors, with astrocyte-specific genes as key targets.

This study shows that tonic and burst firing patterns of the locus coeruleus modulate brain activity and dynamics in mice through distinct mechanisms.

This study shows that chronic adolescent stress increases exploratory behavior and hippocampal gene expression but does not affect acute stress responses in adult mice.

This study characterizes the molecular changes in the mouse hippocampus during the acute stress response using multiomic profiling and identifies rapid resolution of molecular events within 4 hours.

This study uses chemogenetic activation of the locus coeruleus in mice combined with resting-state fMRI to show rapid changes in functional connectivity, particularly in salience and amygdala networks.