Sian N. Duss

This study compares natural arousal and direct locus coeruleus activation in mouse hippocampal CA1, revealing distinct cellular response patterns in astrocytes and neurons.

This paper introduces behavioral flow analysis to detect latent phenotypes in rodent behavior, improving statistical power and transferability across experiments.

The paper shows that hippocampal astrocytes integrate calcium signals from distal processes to somata, influenced by salient events and locus coeruleus activity.

The paper identifies hypothalamic MCH cells as a neural module that tracks and controls exploratory rearing through interactions with locus coeruleus neurons.

The paper shows that noradrenaline release from the locus coeruleus regulates gene expression in the hippocampus via beta-adrenergic receptors, with astrocyte-specific genes as key targets.

This study shows that tonic and burst firing patterns of the locus coeruleus modulate brain activity and dynamics in mice through distinct mechanisms.

This study shows that chronic adolescent stress increases exploratory behavior and hippocampal gene expression but does not affect acute stress responses in adult mice.

This study characterizes the molecular changes in the mouse hippocampus during the acute stress response using multiomic profiling and identifies rapid resolution of molecular events within 4 hours.