Peter Paul De Deyn

Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy

This study uses whole-genome sequencing to identify new genetic loci and structural variants associated with progressive supranuclear palsy, including novel signals in APOE and H1/H2 haplotype region variants.

Age-related memory CD8 T cells induce and track Alzheimers-like neurodegeneration

This paper shows that age-related memory CD8 T cells drive AD-like neurodegeneration upstream of Aβ/pTau in mice and are elevated in human AD patients.

Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression

The paper shows that noradrenaline release from the locus coeruleus regulates gene expression in the hippocampus via beta-adrenergic receptors, with astrocyte-specific genes as key targets.

Chronic adolescent stress increases exploratory behavior but does not change the acute stress response in adult male C57BL/6 mice

This study shows that chronic adolescent stress increases exploratory behavior and hippocampal gene expression but does not affect acute stress responses in adult mice.

PapRIV, a BV-2 microglial cell activating quorum sensing peptide

This study investigates the ability of the quorum sensing peptide PapRIV to activate BV-2 microglia and cross biological barriers, showing in vitro activation and in vivo presence.

Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation

This study uses chemogenetic activation of the locus coeruleus in mice combined with resting-state fMRI to show rapid changes in functional connectivity, particularly in salience and amygdala networks.