Johannes Bohacek

A human-specific microRNA controls the timing of excitatory synaptogenesis

The paper identifies miR-1229-3p as a human-specific microRNA that delays neuronal synaptogenesis by reducing mitochondrial metabolism.

Large-scale prediction of transcription factor binding across human cell types informs regulatory genomics and reveals promiscuous occupancy associated with chromatin contacts

The paper predicts transcription factor binding across 43 human cell types using ATAC-seq data and a new platform, revealing promiscuous occupancy and chromatin contacts.

Hippocampal neuronal and astrocytic responses to noradrenaline and natural arousal

This study compares natural arousal and direct locus coeruleus activation in mouse hippocampal CA1, revealing distinct cellular response patterns in astrocytes and neurons.

GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice

GrimACE is an automated tool for assessing pain and well-being in mice using computer vision, showing high correlation with expert evaluations and detecting pain and treatment effects.

Distinct molecular mechanisms of stress habituation in the mouse hippocampus

This study investigates how repeated stress affects molecular responses in the mouse hippocampus, finding widespread habituation without new adaptive responses or baseline gene expression changes.

A distinct hypothalamus-habenula circuit governs risk preference

The paper identifies a distinct hypothalamus-habenula circuit that governs risk preference in economic decision-making.

Analysis of behavioral flow resolves latent phenotypes

This paper introduces behavioral flow analysis to detect latent phenotypes in rodent behavior, improving statistical power and transferability across experiments.

Centripetal integration of past events by hippocampal astrocytes and its regulation by the locus coeruleus

The paper shows that hippocampal astrocytes integrate calcium signals from distal processes to somata, influenced by salient events and locus coeruleus activity.

Harnessing PROTAC technology to combat stress hormone receptor activation

This paper introduces a novel GR degrader, KH-103, which selectively degrades glucocorticoid receptors and shows improved efficacy over existing inhibitors.

Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions

The paper investigates how manipulating D1 medium spiny neurons affects BOLD dynamics in connected brain regions using resting-state fMRI.

Exploratory rearing is governed by hypothalamic MCH cells according to the locus coeruleus

The paper identifies hypothalamic MCH cells as a neural module that tracks and controls exploratory rearing through interactions with locus coeruleus neurons.

Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression

The paper shows that noradrenaline release from the locus coeruleus regulates gene expression in the hippocampus via beta-adrenergic receptors, with astrocyte-specific genes as key targets.

Locus Coeruleus firing patterns selectively modulate brain activity and dynamics

This study shows that tonic and burst firing patterns of the locus coeruleus modulate brain activity and dynamics in mice through distinct mechanisms.

Chronic adolescent stress increases exploratory behavior but does not change the acute stress response in adult male C57BL/6 mice

This study shows that chronic adolescent stress increases exploratory behavior and hippocampal gene expression but does not affect acute stress responses in adult mice.

Pervasive compartment-specific regulation of gene expression during homeostatic synaptic scaling

This study identifies compartment-specific gene expression changes during synaptic scaling in rat hippocampal neurons, revealing distinct regulatory mechanisms in somatic and process compartments.

Single paternal Dexamethasone challenge programs offspring metabolism and reveals circRNAs as novel candidates in RNA-mediated inheritance

The paper shows acute paternal Dexamethasone exposure alters sperm RNA and offspring metabolism, identifying circRNAs as novel RNA-mediated inheritance candidates.

Molecular roadmap of the healthy stress response in the mouse hippocampus

This study characterizes the molecular changes in the mouse hippocampus during the acute stress response using multiomic profiling and identifies rapid resolution of molecular events within 4 hours.

Optogenetic Activation of Striatal D1/D2 Medium Spiny Neurons Differentially Engages Downstream Connected Areas Beyond the Basal Ganglia

This study uses optogenetics and fMRI to show that D1 and D2 MSNs in the striatum differentially activate brain regions beyond the basal ganglia, revealing complex functional interactions.

Translatomic profiling of the acute stress response: It's a TRAP

The paper reanalyzes TRAP-seq data on acute stress response in hippocampal neurons, finding limited translational changes and no effect of sex or early life stress.

Deep-learning based identification, tracking, pose estimation, and behavior classification of interacting primates and mice in complex environments

This paper introduces a deep learning pipeline for tracking and classifying behaviors of interacting primates and mice in complex environments using video data.

Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation

This study uses chemogenetic activation of the locus coeruleus in mice combined with resting-state fMRI to show rapid changes in functional connectivity, particularly in salience and amygdala networks.