Tissue-scale mechanics controls differentiation strategy and dynamics of epithelial multilayering
Clémentine Villeneuve, Somiéalo Azote, Marga Albu, Matthias Rübsam, Leah C. Biggs, Sabrina Vinzens, Kai Kruse, Anubhav Prakash, Peter Zentis, Elizabeth Lawson-Keister, Gautier Follain, Johanna Ivaska, Carien M. Niessen, M. Lisa Manning, Sara A. Wickström
The paper shows that tissue mechanics control epithelial multilayering by regulating cell differentiation and movement strategies in the developing mouse epidermis.
bioRxiv · Apr 15, 2026 · PreprintCell Biology