Michael A. Trembley

This study shows that RBFOX2 autoregulation is critical for cardiomyocyte differentiation by maturing the transcriptome, and its disruption leads to congenital heart disease.

This study identifies molecular mechanisms of cardiomyocyte aging using single-nucleus RNA-seq, ATAC-seq, and epigenetic analyses in mice, revealing DNA methylation and ESRRG as key regulators.

The paper shows that TBX5 recruits CHD4 to regulate chromatin organization in atrial cardiomyocytes, affecting gene expression and atrial rhythm.

This paper describes a method to generate high-purity, scalable human iPSC-derived cardiomyocytes using a bioreactor, showing improved viability, function, and consistency compared to traditional methods.

This study identifies RBPMS2 as a conserved regulator of alternative splicing that supports myofibril organization and calcium handling in cardiomyocytes across species.

This study shows that sarcomere assembly via ACTN2 and MRTF-SRF signaling promotes cardiomyocyte maturation through a positive feedback loop.