NeurosciencebioRxivPreprint
Stealth liposomes encapsulating a potent ACAT1/SOAT1 inhibitor F12511: pharmacokinetic, biodistribution and toxicity studies in wild-type mice, and efficacy studies in triple transgenic Alzheimer Disease mice.
Adrianna L. De La Torre, Thao Nguyen Thanh Huynh, Catherine C.Y. Chang…·Ta‐Yuan Chang
This study evaluates a nanoparticle-formulated ACAT1 inhibitor in mice, showing brain delivery and reduced AD pathology without toxicity.
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