Author

Adrianna L. De La Torre

Dartmouth CollegeORCID 0000-0003-2470-7687Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Catherine C.Y. ChangiD· 2 shared Ta‐Yuan ChangiD· 2 shared Thao Nguyen Thanh HuynhiD· 2 shared Darcy B. PooleriD· 1 shared Dylan B. NessiD· 1 shared Emma N. FikseiD· 1 shared Kimberley S. SamkoeiD· 1 shared Lionel D. LewisiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Catherine C.Y. ChangORCID

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2 papers

Recent·Most cited

BiochemistryInternational Journal of Molecular SciencesPeer-reviewedDec 21, 2024

Inhibiting the cholesterol storage enzyme ACAT1/SOAT1 in aging Apolipoprotein E4 mice alter their brains inflammatory profiles

Thao Nguyen Thanh Huynh, Emma N. Fikse, Adrianna L. De La Torre…·Ta‐Yuan Chang

This study shows that inhibiting ACAT1/SOAT1 in APOE4 mice reduces brain inflammation by lowering cholesterol esters and TLR4 levels.

9 citations

mouseproteomics

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NeurosciencebioRxivPreprintMay 2, 2023

Stealth liposomes encapsulating a potent ACAT1/SOAT1 inhibitor F12511: pharmacokinetic, biodistribution and toxicity studies in wild-type mice, and efficacy studies in triple transgenic Alzheimer Disease mice.

Adrianna L. De La Torre, Thao Nguyen Thanh Huynh, Catherine C.Y. Chang…·Ta‐Yuan Chang

This study evaluates a nanoparticle-formulated ACAT1 inhibitor in mice, showing brain delivery and reduced AD pathology without toxicity.

2 citations

mouseexperimental assay

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