Author

Klaudia Ciurkot

Imperial College LondonORCID 0000-0001-9857-8553Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 4 Research Focus:variant calling· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Tom EllisiD· 4 shared Xinyu LuiD· 3 shared Anastasiya Malyshava· 2 shared Glen-Oliver F. GowersiD· 2 shared William M. ShawiD· 2 shared Aidan LeesiD· 1 shared Andrew R. HeskethiD· 1 shared Armand Grollemund· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersSynthetic Biology

Tom EllisORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Synthetic Combinatorial Minimisation of Cell Cycle Control in Yeast

Anastasiya Malyshava, Klaudia Ciurkot, Lucas Can_izares Alonso, Armand Grollemund, W. M. Shaw, Matteo Barberis, Tom Ellis

This study minimizes the yeast cell cycle gene set using synthetic genomics, identifying minimal gene combinations that maintain viability and robustness across conditions.

bioRxiv · Jul 27, 2026 · PreprintSynthetic Biology

Iterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes

Xinyu Lu, Klaudia Ciurkot, Glen-Oliver F. Gowers, William M. Shaw, Tom Ellis

The paper demonstrates iterative SCRaMbLE to optimize synthetic genome modules and chromosomes in yeast by selecting for improved growth phenotypes.

Nature Communications · Aug 7, 2025Peer-reviewedSynthetic Biology

Combinatorial Design Testing in Genomes with POLAR-seq

Klaudia Ciurkot, Xinyu Lu, Anastasiya Malyshava, Livia Soro, Aidan Lees, Thomas E. Gorochowski, Tom Ellis

The paper introduces POLAR-seq, a low-cost method to analyze combinatorial genetic libraries by sequencing long amplicons to identify genotype-phenotype relationships in yeast.

bioRxiv · Jun 6, 2024 · PreprintSynthetic Biology

Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand

Benjamin A. Blount, Xinyu Lu, Maureen R M Driessen, Dejana Jovicevic, Mateo I Sanchez, Klaudia Ciurkot, Yu Zhao, Stephanie L. Lauer, Robert M. McKiernan, Glen-Oliver F. Gowers, Fiachra Sweeney, Viola Fanfani, Evgenii Lobzaev, Kim Palacios-Flores, Roy S. K. Walker, , Tom Ellis

The paper constructs a synthetic yeast chromosome XI and demonstrates how non-coding DNA modifications affect cell fitness, enabling on-demand extrachromosomal circular DNA formation.

bioRxiv · Jul 15, 2022 · PreprintSynthetic Biology