William M. Shaw

This study minimizes the yeast cell cycle gene set using synthetic genomics, identifying minimal gene combinations that maintain viability and robustness across conditions.

The paper designs a new T-DNA vector for Arabidopsis thaliana that enables predictable, single-copy transgene integration with reduced genome instability and silencing.

This paper introduces genetic devices for precise control of cell-type ratios and multicellular morphology in synthetic biology systems.

Comparative mushroom genomics and fly-rearing experiments reveal an alternative psilocybin biosynthetic gene cluster in Inocybe corydalina, horizontal transfer of the canonical cluster, and incomplete defense against dipteran larvae.

The paper describes the creation of SINERGY, a synthetic sourdough starter using engineered microbial consortia with division-of-labor modules for biosensing and drug delivery.

The paper demonstrates iterative SCRaMbLE to optimize synthetic genome modules and chromosomes in yeast by selecting for improved growth phenotypes.

This paper introduces synthetic tools for engineering multicellularity in yeast by enabling contact-dependent signaling and adhesion, allowing for the creation of multicellular logic circuits and protein interaction sensors.

The paper demonstrates the design of synthetic genome modules for programmable silencing in yeast using dCreSIR, a system that controls gene expression through loxPsym sites.

This paper develops a synthetic symbiotic co-culture system to engineer bacterial cellulose with programmable functional properties.

The paper constructs a synthetic GPCR signaling system in yeast to predictably tune cellular responses to stimuli using computational and experimental methods.