Author

Scott M. Leighow

Pennsylvania State UniversityORCID 0009-0005-1671-5291Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Justin R. PritchardiD· 3 shared Gavin A Birdsall· 1 shared Haider InamiD· 1 shared Joshua ReynoldsiD· 1 shared Kelly M. WardiD· 1 shared M LeeiD· 1 shared Marta TomaszkiewicziD· 1 shared Megan E. HoneywelliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBioengineering

Justin R. PritchardORCID

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3 papers

Recent·Most cited

Cancer BiologyJournal of Biological ChemistryPeer-reviewedApr 2, 2026

Genome-wide profiling identifies the genetic dependencies of cell death following EGFR inhibition

Sydney A Porto, Gavin A Birdsall, Nicholas W. Harper…·M Lee

This study identifies genetic dependencies of cell death following EGFR inhibition by analyzing functional genomics data.

DOI 10.1016/j.jbc.2026.111414

humanwhole-genome sequencing

𝕏 PostBluesky

BioengineeringbioRxivPreprintOct 31, 2025

Characterizing Variants of Uncertain Drug Resistance (VUDRs) Using Quantitative Measurements at Clinical Exposures

Haider Inam, Marta Tomaszkiewicz, Joshua Reynolds…·Justin R. Pritchard

The paper characterizes Variants of Uncertain Drug Resistance (VUDRs) using quantitative measurements from clinical exposures to imatinib, identifying resistance levels and ancestry-specific variants.

1 citation

humanproteomics

𝕏 PostBluesky

BioengineeringbioRxivPreprintOct 4, 2025

Systemic tumor-targeting gene drive vectors proactively eliminate drug resistance in solid tumors

Scott M. Leighow, Michael T. Hemann, Justin R. Pritchard

This paper develops tumor-targeting gene drive vectors that eliminate drug resistance in solid tumors through systemic delivery, showing durable tumor burden reduction with minimal toxicity.

DOI 10.1101/2025.10.04.680477

humanexperimental assay

𝕏 PostBluesky