Helena Coyle

PRISM is a plasmid-based reporter system for spectral microscopy that labels multiple organelles and provides quantitative metrics to study organelle network dynamics across cell types and conditions.

This study introduces ExVivo PhaseScan to generate high-resolution phase diagrams of physiological protein condensates and reveals how FUS mutations cause liquid-to-solid transitions in stress granules and nucleoli.

This study shows GLP-1R agonists improve mitochondrial health in beta-cells by forming a complex with VAPB and SPHKAP at ER-mitochondria MCSs, leading to mitochondrial remodelling and improved function.