Sierra J. Edgerton

This study presents two whole genome sequencing pipelines to identify and genotype transgene insertion sites in transgenic mice, enabling accurate zygosity determination and breeding strategies.

The paper introduces CUT&TIME, a method to map historical chromatin accessibility in single cells during neurogenesis, revealing early changes in promoter accessibility linked to cell-fate commitment in retinal ganglion cells.

The paper identifies a proliferative region in the fetal human retina that continues to generate neurons late in development, similar to the non-mammalian ciliary marginal zone.