CUT&TIME captures the history of open chromatin indeveloping neurons
Kiara C. Eldred, Matthew Wooten, Derek H. Janssens, Joshua Hahn, Shane J. Neph, Sierra J. Edgerton, Gracious Wyatt-Draher, Stephanie M. Sherman, Jane E. Ranchalis, Andrew B. Stergachis, Thomas A. Reh, Steven Henikoff
The paper introduces CUT&TIME, a method to map historical chromatin accessibility in single cells during neurogenesis, revealing early changes in promoter accessibility linked to cell-fate commitment in retinal ganglion cells.
bioRxiv · Aug 29, 2025 · PreprintDevelopmental Biology