David P. Waterman

The paper identifies Esc1-mediated telomere anchoring as a mechanism regulating telomere clustering in yeast during metabolic shifts to quiescence.

This study shows that prolonged cell cycle arrest in yeast after DNA damage requires both DNA damage checkpoint (DDC) and spindle assembly checkpoint (SAC) proteins, with a handoff from DDC to SAC components after 15 hours.

The paper uses fluorescent markers to study DSB formation and repair dynamics in yeast, finding that DSB foci coalesce and dissociate without requiring Rad2 protein.

The paper investigates CRISPR-Cas9 cleavage in yeast and human cells, revealing templated insertions and strand-specific indel patterns influenced by gRNA orientation and repair factors.