Angela Taddei

SAD-6/ATRX enables broad genome surveillance and defense in fungi

This paper shows that the fungal ATRX ortholog SAD-6 uses a unique histone H4 variant for genome surveillance and defense, revealing its role in various genomic regions and a repeat-induced point mutation pathway.

Esc1-mediated anchoring regulates telomere clustering in response to metabolic changes.

The paper identifies Esc1-mediated telomere anchoring as a mechanism regulating telomere clustering in yeast during metabolic shifts to quiescence.

A radial map of the budding yeast genome reveals novel organizational principles

The paper uses GPSeq to map the budding yeast genome's radial organization, revealing that centromeres and telomeres constrain chromatin positioning, and GC-content organizes chromatin in their absence.

Single-nucleosome imaging reveals principles of transient multiscale chromatin unfolding triggered by histone ADP-ribosylation at DNA lesions

The paper uses live-cell imaging to show DNA damage triggers chromatin unfolding via histone ADP-ribosylation, enabling repair access.

Rad52 Acts as an Assembly Chaperone to Form and Stabilize Rad51 Filaments Through a Large C-Terminus 85-Residue Segment

This study identifies an 85-residue segment of Rad52 that facilitates Rad51 filament formation and stability through structural and functional analyses in yeast.

Rad52 sorts and stacks Rad51 at the DNA junction to promote homologous recombination

This study reveals how Rad52 sorts and stacks Rad51 at DNA junctions to enhance homologous recombination by promoting Rad51 binding to RPA-coated ssDNA.

Remodeling of perturbed chromatin can initiate de novo transcriptional and post-transcriptional silencing

The paper shows that perturbed chromatin in Neurospora crassa can trigger de novo transcriptional and post-transcriptional silencing, mediated by SAD-6, a chromatin remodeler.

Anchoring of parasitic plasmids to inactive regions of eukaryotic chromosomes through nucleosome signal

The paper identifies how the 2μ plasmid in yeast binds to inactive chromosomal regions through nucleosome signals and RNA Pol II depletion, revealing a stable and rapid tethering mechanism.

Exogenous chromosomes reveal how sequence composition drives chromatin assembly, activity, folding and compartmentalization

This study shows that bacterial chromosomes can undergo chromatin assembly, activity, looping, and compartmentalization in yeast, driven by their sequence composition.

Expanding heterochromatin reveals discrete subtelomeric domains delimited by chromatin landscape transitions

The paper shows that H3K79 methylation blocks Sir3 spreading in yeast, revealing discrete subtelomeric domains defined by chromatin transitions.