Reinnier Padilla

This study investigates the role of H3K36 methylation in epigenome integrity by analyzing knockout mouse cells, revealing its impact on enhancer activity, gene body repression, and genome compartmentalization.

ChIPbinner provides an R package for analyzing broad histone marks by binning the genome into uniform windows, enabling unbiased comparison between samples and identification of differential bins.

The paper systematically perturbs H3K36 methyltransferases in mouse mesenchymal stem cells to reveal their distinct roles in H3K36 methylation states and genomic distribution.

This study shows that Snrpb mutations cause craniofacial defects by disrupting splicing of genes involved in P53 regulation and craniofacial development.