Gerry A. Shipman

This study investigates the role of H3K36 methylation in epigenome integrity by analyzing knockout mouse cells, revealing its impact on enhancer activity, gene body repression, and genome compartmentalization.

The paper systematically perturbs H3K36 methyltransferases in mouse mesenchymal stem cells to reveal their distinct roles in H3K36 methylation states and genomic distribution.

The paper uses Drosophila to study human HIPKs, finding that hHIPK1 and hHIPK2 can rescue lethality, while hHIPK3 and hHIPK4 only rescue minor defects, and that HIPKs inhibit Polycomb-group complex activity.