Federico Gonzãlez

The paper shows that inhibiting miR-128-3p improves muscle function and reduces aging-related pathology in multiple models.

The paper identifies pre-established chromatin regions in human ESCs that enable rapid activation of lineage-specific genes during differentiation.

This paper develops a human organoid model of early PDAC that identifies genetic and epigenetic barriers to lineage plasticity, showing CDKN2A loss is essential with KRAS/TP53 mutations and TET1 suppression links ERK signaling to transcription factor silencing.

This study creates a C4A overexpressing neuroimmune cortical organoid model that exhibits schizophrenia endophenotypes like inflammation and synaptic pruning.

The paper describes CRISPR/Cas9-generated Duchenne muscular dystrophy cell models for drug screening, showing successful exon deletion and utrophin upregulation.