Author

Sandrine Legault

University of ChicagoORCID 0009-0005-6170-9149Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam M. DamryiD· 1 shared Bryan C. DickinsoniD· 1 shared Joshua A. PixleyiD· 1 shared Matthew J. StylesiD· 1 shared Michael C. ThompsoniD· 1 shared Natalie K. GotoiD· 1 shared Roberto A. ChicaiD· 1 shared Serena E. HuntiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperBiophysics

Adam M. DamryORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintAug 6, 2026

PANCS-Inhibitors: A rapid method to directly select for protein-protein interaction inhibitors

Matthew J. Styles, Victoria Cochran Xie, Sandrine Legault…·Bryan C. Dickinson

PANCS-Inhibitors rapidly selects molecules that directly disrupt pre-formed protein-protein interactions, demonstrating effectiveness against three oncogenic PPIs.

DOI 10.64898/2026.08.05.743105

protein structureexperimental assay

𝕏 PostBluesky

BiophysicsProtein Engineering Design and SelectionPeer-reviewedJan 1, 2026

Mapping Functional Dynamics Hotspots for Protein Engineering with NMR Peak Intensity Analysis

Adam M. Damry, Serena E. Hunt, Sandrine Legault…·Roberto A. Chica

This study uses NMR peak intensity analysis to identify functional dynamics hotspots in proteins, showing that specific structural flexibility correlates with function in red fluorescent proteins.

1 citation

proteomicsexperimental assay

𝕏 PostBluesky