Serena E. Hunt

This study uses NMR peak intensity analysis to identify functional dynamics hotspots in proteins, showing that specific structural flexibility correlates with function in red fluorescent proteins.

This study shows that distal mutations improve enzyme catalysis by enhancing substrate binding and product release, working with active-site mutations to increase overall activity.

The paper investigates how distal mutations in a retro-aldolase affect loop dynamics and catalytic efficiency, showing an epistatic effect when combined with active-site mutations.