Allyson Quinn Ryan

SpinePy enables automated 3D spatiotemporal quantification of multicellular in vitro systems

SpinePy provides a framework for 3D spatiotemporal quantification of multicellular systems by aligning data to dynamic internal coordinate systems, revealing patterning classes influenced by gastruloid volume.

Timely neurogenesis enables increased nuclear packing order during neuronal lamination

The paper shows that nuclear shape changes and packing order during neurogenesis are critical for retinal lamination in zebrafish.

Tissue scale properties of the extracellular matrix regulates nuclear shape, organisation and fate in the embryonic midline sutures

The paper investigates how extracellular matrix properties influence nuclear shape, organization, and cell fate in embryonic midline sutures through physical and genetic analyses.

Lumen expansion facilitates epiblast-primitive endoderm fate specification in the mouse blastocyst formation.

This study shows that lumen expansion in mouse blastocysts is critical for epiblast and primitive endoderm fate specification and spatial segregation.