Ryan G. Savill

This study shows that mammalian body axis elongation is driven by a posterior actin cap that constrains cell proliferation forces, differing from other vertebrates.

SpinePy provides a framework for 3D spatiotemporal quantification of multicellular systems by aligning data to dynamic internal coordinate systems, revealing patterning classes influenced by gastruloid volume.

The paper identifies early metabolic imbalances as drivers of phenotypic variation in stembryos and shows how metabolic interventions can correct aberrant morphology and lineage bias.