Author

Spencer T. Shah

Broad InstituteORCID 0009-0002-9082-3969Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Spencer T. Shah1 paper · Rice University

Biology Disciplines

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Bioengineering· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 3 Organism:human· 3 Research Focus:perturbation response prediction· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

John G. DoenchiD· 3 shared Laura M. DrepanosiD· 3 shared E L KaplaniD· 2 shared Ganna ReintiD· 2 shared Sarra MerzoukiD· 2 shared Smriti SrikanthiD· 2 shared Allison Uebele· 1 shared Audrey L GriffithiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersGenomics

John G. DoenchORCID

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3 papers

Recent·Most cited

Balancing off-target and on-target considerations for optimized Cas9 CRISPR knockout library design

Laura M. Drepanos, Smriti Srikanth, Eleanor G. Kaplan, Spencer T. Shah, Berta Escude Velasco, Sarra Merzouk, John G. Doench

The paper presents a guide selection strategy to optimize Cas9 CRISPR knockout library design by balancing on-target and off-target activity, resulting in an updated validated library for the human genome.

Cell Genomics · Mar 25, 2026Peer-reviewedGenomics

Optimized parameters for Cas9 CRISPR interference library design

Smriti Srikanth, Fengyi Zheng, Laura M. Drepanos, Spencer T. Shah, E L Kaplan, Daytan Gibson, Grace O Lynch, Allison Uebele, Ganna Reint, Sarra Merzouk, John G. Doench

This study designs an optimized Cas9 CRISPRi library by improving on-target scoring and analyzing off-target effects using updated datasets and methods.

bioRxiv · Feb 26, 2026 · PreprintBioengineering

Activity-based selection for enhanced base editor mutational scanning

E L Kaplan, Ryan J. Steger, Spencer T. Shah, Laura M. Drepanos, Audrey L Griffith, Ganna Reint, John G. Doench

This paper introduces an activity-based selection method to improve base editing efficiency and precision in identifying functional mutations.

Nature Genetics · Oct 14, 2025Peer-reviewedGenetics