Author

E L Kaplan

Broad InstituteORCID 0009-0000-9949-6613Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Organism:human· 2 Research Focus:perturbation response prediction· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Ganna ReintiD· 2 shared John G. DoenchiD· 2 shared Laura M. DrepanosiD· 2 shared Spencer T. ShahiD· 2 shared Allison Uebele· 1 shared Audrey L GriffithiD· 1 shared Daytan GibsoniD· 1 shared Fengyi ZhengiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioengineering

Ganna ReintORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintFeb 26, 2026

Optimized parameters for Cas9 CRISPR interference library design

Smriti Srikanth, Fengyi Zheng, Laura M. Drepanos…·John G. Doench

This study designs an optimized Cas9 CRISPRi library by improving on-target scoring and analyzing off-target effects using updated datasets and methods.

2 citations

humanCRISPR screen

𝕏 PostBluesky

GeneticsNature GeneticsPeer-reviewedOct 14, 2025

Activity-based selection for enhanced base editor mutational scanning

E L Kaplan, Ryan J. Steger, Spencer T. Shah…·John G. Doench

This paper introduces an activity-based selection method to improve base editing efficiency and precision in identifying functional mutations.

9 citations

humanCRISPR screen

𝕏 PostBluesky