Hiroyuki Aoki

This paper uses MM-TPP to show that cholesteryl hemisuccinate broadly stabilizes membrane proteins across different systems and membrane mimetics.

This paper introduces Peptergents, a detergent-free method for native membrane proteomics that preserves protein structure and function, enabling better analysis of membrane proteins and their interactions.

This paper uses membrane-mimetic proteomics to show that AD-related membrane proteome changes are enriched in APP mice, and M1 receptor activation selectively affects disease-altered membrane networks.

This study compares seven membrane proteomic workflows, finding that solid-phase methods capture more total proteins while membrane mimetics enrich membrane proteins, with Peptidisc excelling in detecting dysregulated membrane proteins in diseased liver.

This study generates CHCHD2 T61I mutant mice to model Parkinson's disease, finding mitochondrial dysfunction and metabolic shifts towards glycolysis.

This paper introduces MM-TPP, a method to map membrane protein-ligand interactions using Peptidisc and thermal proteome profiling, showing it detects specific ligand effects on ABC transporters and GPCRs better than detergent-based TPP.

This study identifies dysregulated membrane proteins in liver disease using peptidisc-based proteomics in mice, highlighting lipid metabolism and xenobiotic processing pathways.