Angus C. Wilson

METTL3 promotes human coronavirus replication through an interferon-independent mechanism

This study shows METTL3 promotes human coronavirus replication without requiring interferon signaling.

Extended poly(A) tails are a shared feature of herpesvirus mRNAs

The paper uses nanopore sequencing to show herpesvirus mRNAs have longer poly(A) tails than cellular or other viral transcripts, suggesting a unique mechanism for enhancing gene expression.

Herpes simplex virus-1 fluidizes the nucleus enabling condensate formation

This study shows HSV-1 protein ICP4 increases nuclear fluidity to enable condensate formation, supporting viral replication.

Transcriptional consequences of herpes simplex virus 1 ICP4 inducible expression in uninfected cells

This study examines how HSV-1 ICP4 expression in uninfected cells alters host gene expression through RNA-Seq, identifying differentially expressed genes and validating findings against infected cell data.

TDP-43 promotes efficient HSV-1 replication in human DRG-derived neurons

This study shows TDP-43 promotes HSV-1 replication in human DRG-derived neurons by enhancing viral mRNA splicing, but not in epithelial cells or fibroblasts.

Calibrated analysis framework for nanopore direct RNA sequencing uncovers cell-specific m6A proportions at conserved sites

The paper evaluates Dorado basecalling for nanopore DRS to detect m6A modifications in RNA, finding that stringent filtering improves accuracy and revealing cell-type differences in m6A proportions at conserved sites.

Nanopore Guided Annotation of Transcriptome Architectures

The paper develops a novel method for high-resolution transcriptome annotation from Nanopore DRS data, demonstrating its effectiveness on both synthetic and real datasets, including a new annotation of human adenovirus type F 41.

Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

The paper uses direct RNA long-read sequencing to show m6A modifications on adenovirus RNA are necessary for efficient splicing.

Topoisomerase 2-dependent nuclear DNA damage shapes extracellular growth factor responses through AKT phosphorylation dynamics to control virus latency

The paper shows that Topoisomerase 2-dependent DNA damage and AKT phosphorylation dynamics regulate HSV-1 latency by integrating extracellular signals and nuclear DNA damage.