Author

Ayaha Itokawa

Fred Hutch Cancer CenterORCID 0009-0005-8219-800XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Anna-Lena B.G. VigiliD· 1 shared Brock J. McKinneyiD· 1 shared Douglas B. FoxiD· 1 shared James V. AlvareziD· 1 shared Josh Wu· 1 shared Kelley R. McCutcheoniD· 1 shared Lucas B. SullivaniD· 1 shared Oliver J. NewsomiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Anna-Lena B.G. VigilORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintNov 17, 2025

Recurrent Breast Cancer Cells Depend on De novo Pyrimidine Biosynthesis to Suppress Ferroptosis

Kelley R. McCutcheon, Josh Wu, Yasemin Ceyhan Ozdemir…·James V. Alvarez

This study identifies de novo pyrimidine synthesis as a metabolic vulnerability in recurrent breast cancer cells that suppresses ferroptosis, with DHODH inhibition selectively targeting these cells.

DOI 10.1101/2025.11.17.688927

humanbulk RNA-seq

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