Anna-Lena B.G. Vigil

Recurrent Breast Cancer Cells Depend on De novo Pyrimidine Biosynthesis to Suppress Ferroptosis

This study identifies de novo pyrimidine synthesis as a metabolic vulnerability in recurrent breast cancer cells that suppresses ferroptosis, with DHODH inhibition selectively targeting these cells.

Converging cytokine and metabolite networks shape asymmetric T cell fate at the term human maternal-fetal interface

The paper identifies cytokine and metabolite networks that regulate T cell fate at the human maternal-fetal interface, showing how they restrain T cells in an antigen-independent manner.

The regulatory landscape of Arabidopsis thaliana roots at single-cell resolution

This study uses single-cell ATAC-seq to analyze chromatin accessibility in Arabidopsis thaliana roots, revealing cell type-specific regulatory landscapes and integrating them with transcriptomes to infer gene regulatory networks.