The fitness landscape of a Form II Rubisco in a photosynthetic bacterium guides engineering of oxygen tolerance
Ute A. Hoffmann, Axel Knave, Anna Zoey Schuppe, Sebastià Capó‐Bauçà, Pere Aguiló‐Nicolau, Karen Schriever, Anna Karlsson, Michele Russo, Emil Sporre, Mami Matsuda, Rui Miao, Tomohisa Hasunuma, Jeroni Galmés, Per‐Olof Syrén, Elton Paul Hudson
The paper screens variants of a Form II Rubisco to improve oxygen tolerance, identifies key mutations, and uses a transformer model to guide engineering.
Science Advances · Sep 4, 2026Peer-reviewedBiochemistry