Rui Miao

The paper screens variants of a Form II Rubisco to improve oxygen tolerance, identifies key mutations, and uses a transformer model to guide engineering.

This study investigates the metabolic and physiological effects of L-lysine on Synechocystis sp. PCC 6803, identifying key genes involved in Lys resistance and metabolic disruption.

This study shows that alka(e)nes are essential for maintaining membrane lipid homeostasis and photosynthetic resilience to high light in cyanobacteria.

The paper screens CRISPR interference mutants in Synechocystis sp. PCC 6803 across trophic conditions, revealing tradeoffs between growth rate and robustness and identifying condition-specific gene functions.

This study engineered cyanobacteria to convert CO2 into secreted short-to medium-chain hydrocarbons using synthetic metabolic pathways, achieving 230 mg/L of 1-alkene with 15% carbon partitioning.