Wing Hei Au

The paper identifies HUWE1, USP33, and USP20 as negative regulators of autophagy/mitophagy through cross-platform screening and validates their roles in neurodegeneration using multiple models.

This study shows that Clu/Clu1 proteins form mitochondrial-associated granules and regulate mitochondrial protein translation by interacting with ribosomes and mRNAs during metabolic transitions.

This study shows that activating the Keap1/Nrf2 pathway reduces mitochondrial dysfunction and motor deficits in C9orf72 ALS/FTD models and patient-derived neurons.